Evaluation of the blood coagulation control system and protein S K196E mutation during twin pregnancy in Japanese women

Abstract

Recently, venous thromboembolism has become a problem as a cause of perinatal maternal death. Thrombosis is more likely to occur during pregnancy due to pressure on the veins by the uterus and rest, and the risk is even higher in multiple pregnancies. It is also known that during pregnancy, the coagulation control system is suppressed and the risk of thrombosis is enhanced by elevated estrogen. However, the dynamics of coagulation control factors such as protein S, protein C, and antithrombin in pregnant Japanese women remain unclear. Another strong risk factor for thrombosis is congenital thrombophilia. Among these, type II PS deficiency, which is caused by genetic polymorphisms of the PS gene, such as PS Tokushima (K196E). The K196E polymorphism is unique to the Japanese population and is reported to occur in about 1 in 55 people. In this study, we will clarify the changes in antigen levels and activities of coagulation control factors, while considering the influence of type II PS deficiency on the coagulation system in pregnant Japanese women. The National Center for Child Health and Development has a wealth of experience in delivery management, and the National Cerebral and Cardiovascular Center has a wealth of experience in basic research. The cooperation of these two facilities will make this research possible.

Perspectives

• To provide standard values of antigen levels and activities of coagulation control factors in Japanese pregnant women with twins
• To make possible identification of high-risk patients for thrombosis in perinatal care based on standard values.

Comments from principal researcher

Comment：The National Center for Child Health and Development manages over 2000 deliveries per year. In addition, the National Cerebral and Cardiovascular Center has a rich track record in basic research. We would like to make every effort to accumulate data that can give back as much as possible to the patients who come to our hospital with trust.

Shared Researchers

• Keiko Maruyama Department of Molecular Pathogenesis, National Cerebral and Cardiovascular Center
• Katsusuke Ozawa Center for Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development